Natural latex usually contains protein with a mass fraction of 0.01~0.02, which can cause allergies in rubber grommets contacts. Due to increased use in recent years, allergic events occur frequently, and the allergic rate is 12.5%, of which 2.5% have allergies, 10% in blood. Produce antibodies. Allergic reactions are mainly soluble (extracted) proteins remaining in latex products. Studies have shown that allergic symptoms do not occur when the residual soluble protein fraction in rubber grommets is less than 110×10-6. However, the mass fraction of soluble protein remaining in the latex produced by centrifugation and its products is much larger than 110×10-6.

The protein of the latex can be effectively reduced by using enzymes, radiation, multiple centrifugation and the like. At present, only a few countries in the world have successfully developed low-protein A latex and its products, and Malaysia is the main producer of low-protein latex.